Cas 103-63-9 (2-Bromoethyl)Benzene
Cas 103-63-9 (2-Bromoethyl)Benzene
Cas 103-63-9 (2-Bromoethyl)Benzene
Cas 103-63-9 (2-Bromoethyl)Benzene
Cas 103-63-9 (2-Bromoethyl)Benzene

Cas 103-63-9 (2-Bromoethyl)Benzene

(2-Bromoethyl)benzene (CAS: 103-63-9) is an important organic compound commonly used in chemical synthesis, pharmaceutical research, and the production of pharmaceutical intermediates. It features a bromoethyl group attached to a benzene ring, making it an essential building block for the synthesis of a variety of bioactive molecules and pharmaceutical agents. This compound is widely utilized in medicinal chemistry and drug discovery for the development of new compounds with therapeutic potential.

Chemical Structure and Properties


(2-Bromoethyl)benzene, with the molecular formula C8H9Br, is a bromoalkylated aromatic compound. It consists of a benzene ring attached to an ethyl group, which carries a bromine atom at the second position (relative to the ethyl group). This unique structure makes it highly reactive in nucleophilic substitution reactions and other organic transformations.


1. Molecular Formula: C8H9Br

2. CAS Number: 103-63-9

3. Appearance: Colorless to pale yellow liquid.

4. Purity: 99% (High purity for research and synthesis).

5. Solubility: Soluble in ethanol, chloroform, and ether; sparingly soluble in water.

The presence of the bromoethyl group makes this compound a versatile intermediate for various synthetic routes.


Applications and Uses


(2-Bromoethyl)benzene is primarily used as an intermediate in the synthesis of several pharmaceutical agents and organic compounds. Its wide applications span across medicinal chemistry, chemical synthesis, and the creation of complex organic molecules.

1. Pharmaceutical Synthesis: (2-Bromoethyl)benzene is often used in the synthesis of pharmaceutical intermediates and as a precursor for the development of medicinal compounds. Its ability to undergo nucleophilic substitution reactions makes it a key building block in the creation of new drugs.

2. Chemical Reactions: This compound is widely employed in organic synthesis, particularly in Suzuki reactions, Wittig reactions, and Grignard reagent synthesis. It also participates in alkylation reactions, contributing to the formation of more complex organic molecules.

3. Synthesis of Aromatic Compounds: Due to the presence of the bromine atom, (2-Bromoethyl)benzene is used in the synthesis of substituted aromatic compounds and as a reactive intermediate in the formation of functionalized benzene derivatives.

4. Research and Development: It is an essential reagent in medicinal chemistry and research for the synthesis of bioactive molecules with potential therapeutic properties. Researchers use it as an intermediate in the design of new drugs with a variety of applications in cancer therapy, neurology, and antibacterial treatments.


Synthesis Pathways


The synthesis of (2-Bromoethyl)benzene is generally straightforward and involves the bromination of ethylbenzene.

1. Bromination of Ethylbenzene: (2-Bromoethyl)benzene can be synthesized by reacting ethylbenzene with bromine (Br2) in the presence of a radical initiator or light to selectively introduce a bromine atom at the second position of the ethyl group, resulting in (2-Bromoethyl)benzene.

2. Further Modifications: Once synthesized, (2-Bromoethyl)benzene can undergo various organic transformations, such as nucleophilic substitution, reduction, and cross-coupling reactions to generate more complex molecules for medicinal or industrial use.




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